COVID-19 and thrombosis: searching for evidence
Bright Thilagar, Mohamad Beidoun, Ruben Rhoades, Scott Kaatz
Abstract
Early in the pandemic, COVID-19-related increases in rates of venous and arterial thromboembolism were seen. Many observational studies suggested a benefit of prophylactic anticoagulation for hospitalized patients using various dosing strategies. Randomized trials were initiated to compare the efficacy of these different options in acutely ill and critically ill inpatients as the concept of immune-mediated inflammatory microthrombosis emerged. We present a case-based review of how we approach thromboembolic prophylaxis in COVID-19 and briefly discuss the epidemiology, the pathophysiology, and the rare occurrence of vaccine-induced thrombotic thrombocytopenia.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ThrombosisMedicine2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyIntensive care medicineInternal medicineOutbreakDiseaseInfectious disease (medical specialty)Venous Thromboembolism Diagnosis and ManagementHeparin-Induced Thrombocytopenia and ThrombosisCOVID-19 Clinical Research Studies