Remote sp<sup>2</sup> C–H Carboxylation via Catalytic 1,4-Ni Migration with CO<sub>2</sub>
Marino Börjesson, Daniel Janssen‐Müller, Basudev Sahoo, Yaya Duan, Xue‐Qiang Wang, Rubén Martı́n
Abstract
A remote catalytic reductive sp 2 C–H carboxylation of arenes with CO 2 (1 bar) via 1,4-Ni migration is disclosed. This protocol constitutes the first catalytic 1,4-Ni migration reported to date, thus offering new vistas in the Ni-catalyzed reductive coupling arena while providing an unconventional new platform for incorporating electrophilic sites at remote sp 2 C–H linkages.
Topics & Concepts
ChemistryCarboxylationCatalysisElectrophileMedicinal chemistryCombinatorial chemistryCoupling (piping)StereochemistryOrganic chemistryMechanical engineeringEngineeringCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCO2 Reduction Techniques and Catalysts