Nickel-Catalyzed Direct Cross-Coupling of Aryl Sulfonium Salt with Aryl Bromide
Nana Ma, Jing‐Ao Ren, Xiang Liu, Xue‐Qiang Chu, Weidong Rao, Zhi‐Liang Shen
Abstract
The direct cross-couplings of aryl sulfonium salts with aryl halides could be achieved by using nickel as a reaction catalyst. The reactions proceeded efficiently via C-S bond activation in the presence of magnesium turnings and lithium chloride in THF at ambient temperature to afford the corresponding biaryls in moderate to good yields, potentially serving as an attractive alternative to conventional cross-coupling reactions employing preprepared organometallic reagents.
Topics & Concepts
ArylChemistrySulfoniumCatalysisHalideNickelReagentBromideSalt (chemistry)MagnesiumChlorideCoupling reactionCombinatorial chemistryPolymer chemistryInorganic chemistryOrganic chemistryAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques