Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors
Dilka Liyana Arachchige, Sushil K. Dwivedi, M.G.J. Waters, Sophia Jaeger, J. Peters, Daniel R. Tucker, Micaela Geborkoff, Thomas Werner, Rudy L. Luck, Bhaskar Godugu, Haiying Liu
Abstract
Probes A and B were developed for NAD(P)H sensing, exhibiting responsive near-infrared emissions with minimal photodamage and effective tissue penetration. Probes C , D , and E showed reduced responsiveness to NAD(P)H.
Topics & Concepts
CyanineFluorescenceChemistryPhotochemistryAbsorption (acoustics)InfraredNAD+ kinaseThiopheneAutofluorescenceAnalytical Chemistry (journal)Materials scienceOrganic chemistryEnzymeOpticsPhysicsComposite materialMolecular Sensors and Ion DetectionNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials