Inversion of the Axial Information during Oxidative Aromatization in the Synthesis of Axially Chiral Biaryls with Organocatalysis as a Key Step
Seitaro Koshino, Akira Takikawa, Keiichi Ishida, Tohru Taniguchi, Kenji Monde, Eunsang Kwon, Shigenobu Umemiya, Yujiro Hayashi
Abstract
The pot-economical, highly enantioselective synthesis of axially chiral biaryls was developed by using one-pot organocatalyst-mediated domino and aromatization reactions as key steps. The axial information of the precursor, which also has central chirality, was completely inverted in the final biaryls. The inversion of the axial information occurred in the conversion of the central chirality to the axial chirality of an oxidative aromatization step.
Topics & Concepts
AromatizationEnantioselective synthesisAxial chiralityChirality (physics)Axial symmetryChemistryOxidative phosphorylationInversion (geology)DominoCatalysisOrganic chemistryChiral perturbation theoryPhysicsGeometryMathematicsParticle physicsGeologyNambu–Jona-Lasinio modelPaleontologyBiochemistryPionStructural basinAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySynthesis and Properties of Aromatic Compounds