NHC-catalyzed [4 + 2] annulations of allenoates and 2,3-dioxopyrrolidine derivatives
Xue Song, Yangxu Chen, Fangfang Lu, Kai Zhang, Chenxia Yu, Tuanjie Li, Changsheng Yao
Abstract
A facile NHC-catalyzed [2 + 4] annulation of allenoates with 2,3-dioxypyrrolidine derivatives was discovered, which paved a new avenue for the construction of highly substituted pyranopyrrole with moderate to good yields, high atom economy and mild reaction conditions.
Topics & Concepts
AnnulationChemistryCatalysisCombinatorial chemistryAtom (system on chip)Medicinal chemistryOrganic chemistryComputer scienceParallel computingN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods