Polydopamine-based molecularly imprinted electrochemical sensor for the highly selective determination of ecstasy components
Chen Li, Dongfang Han, Dongfang Han, Zhifang Wu, Zhishan Liang, Fangjie Han, Ke Chen, Wencai Fu, Dongxue Han, Dongxue Han, Yukai Wang, Li Niu
Abstract
electrochemical polymerization with the safe chemical DA as the polymerization monomer and the uncontrolled pharmaceutical intermediate 3,4-methylenedioxyphenethylamine (MDPEA) as the template molecule, which can provide a great quantity of specific binding sites and expand the practical application of the sensor. Due to the superior affinity of MIP@PDA to the target, the proposed sensor displayed excellent analytical performance, with LODs of 37 nM and 54 nM for the determination of MDA and MDMA, respectively. Additionally, this sensor presented suitable selectivity, stability, reproducibility and detection ability in practical urine samples, which suggested that it is a promising candidate as a rapid diagnostic method in drug investigations.