Hemp sprout-derived exosome-like nanovesicles as hepatoprotective agents attenuate liver fibrosis
Ji-Su Kim, Jung‐Young Eom, Hyun‐Woo Kim, Je‐Won Ko, Eui‐Ju Hong, Mun-Nyeon Kim, Jihoon Kim, Do‐Kyun Kim, Hyo‐Jung Kwon, Young‐Eun Cho
Abstract
) were orally administered for 5 weeks to mice with NAFLD induced by feeding them a Western diet (WD; a fat- and cholesterol-rich diet) and fat-, fructose-, and cholesterol-rich (FFC) diet for 8 weeks. Importantly, the administration of HSNVs markedly reduced oxidative stress and fibrosis marker proteins in NAFLD mouse models and LX2 cells. Furthermore, treatment with HSNVs prevented a significant decrease in the quantity of gut barrier proteins and endotoxin levels in NAFLD mouse models. For the first time, these results demonstrate that HSNVs can exhibit a hepatoprotective effect against gut leakiness and WD/FFC-induced liver fibrosis by inhibiting oxidative stress and reducing fibrosis marker proteins.