Chiral synthetic unprecedented spiro[indoline-2,3′-thiophen]-3-ones <i>via</i> an organocatalytic asymmetric sulfa-Michael/aldol cascade reaction
Mao Zhang, Xing‐Hai Fei, Guiping Yang, Cheng Lin, Wenjie Li, Ming-Liang Rao, Meng Zhou, Chong Zhao, Bin He, Yong‐Long Zhao
Abstract
A cinchona-derived squaramide-catalyzed asymmetric sulfa-Michael/aldol cascade reaction of 2-ylideneoxindoles with 1,4-dithiane-2,5-diol was developed to realize the chiral synthesis of spiro[indoline-2,3′-thiophen]-3-ones.
Topics & Concepts
IndolineChemistryAldol reactionCascadeOrganocatalysisMichael reactionCascade reactionCombinatorial chemistryOrganic chemistryStereochemistryCatalysisEnantioselective synthesisChromatographyOrganic and Inorganic Chemical ReactionsSynthesis of heterocyclic compoundsSulfur-Based Synthesis Techniques