Effect of cysteine thiols on the catalytic and anticancer activity of Ru(<scp>ii</scp>) sulfonyl-ethylenediamine complexes
Feng Chen, Isolda Romero‐Canelón, Abraha Habtemariam, Ji‐Inn Song, Samya Banerjee, Guy J. Clarkson, Lijiang Song, Ivan Prokeš, Peter J. Sadler
Abstract
-EnBz)Cl] with L-buthionine sulfoximine (L-BSO), an inhibitor of GSH synthesis, partially restored the anticancer activity towards A2780 ovarian cancer cells. Complex 2 caused a concentration-dependent G1 phase cell cycle arrest, and induced a significant level of reactive oxygen species (ROS) in A2780 human ovarian cancer cells. The amount of induced ROS decreased with increase in GSH concentration, perhaps due to the formation of the dinuclear Ru-SG complex.
Topics & Concepts
EthylenediamineSulfonylChemistryCysteineCatalysisMedicinal chemistryThiolCombinatorial chemistryOrganic chemistryEnzymeAlkylMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMagnetism in coordination complexes