Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca<sup>2+</sup>Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum
Kenta Yokoi, Kohei Yamaguchi, Masakazu Umezawa, Koji Tsuchiya, Shin Aoki
Abstract
and CGP37157 (termed paraptosis II herein) proceeds via a signaling pathway different from that of the previously known paraptosis induced by celastrol, a process that negligibly involves membrane fusion between mitochondria and the ER (termed paraptosis I herein).
Topics & Concepts
Endoplasmic reticulumMitochondrionInner mitochondrial membraneChemistryJurkat cellsCell biologyBiochemistryBiologyT cellImmune systemImmunologyMitochondrial Function and PathologyATP Synthase and ATPases ResearchRNA and protein synthesis mechanisms