Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
Deepyan Chatterjee, F.J.W. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn
Abstract
functions as a decoy, but truncated CSP molecules may be an approach for malaria vaccination.
Topics & Concepts
SubdominantCircumsporozoite proteinImmunodominanceEpitopeBiologyMalariaPlasmodium falciparumDecoyPlasmodium (life cycle)VirologyImmune systemAntibodyImmunologyParasite hostingGeneticsReceptorComputer scienceWorld Wide WebMalaria Research and ControlHIV Research and TreatmentMosquito-borne diseases and control