YAP promotes AP-1 expression in tubular epithelial cells in the kidney
Yang Liu, Chunhua Xu, Jinhong Li, Yu Zhang, Xiaohua Wang, Yang Wang, Jinzhong Qin, Zhihua Zheng, Yin Xia
Abstract
Yes-associated protein (YAP) activation leads to tubular injury, renal inflammation, and fibrosis, but the underlying mechanisms are not fully understood. We now provide genetic evidence that YAP promotes activator protein-1 expression and that Fosl1 is the primary target of YAP in renal tubular cells.
Topics & Concepts
Activator (genetics)Cell biologyInflammationFibrosisKidneyProtein expressionKidney developmentBiologyCancer researchMedicinePathologyGeneImmunologyEndocrinologyGeneticsEmbryonic stem cellHippo pathway signaling and YAP/TAZGenital Health and Disease