FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway
Zhengtong Lv, Miao Wang, Huimin Hou, Guyu Tang, Haozhe Xu, Xuan Wang, Yuan Li, Jianye Wang, Ming Liu
Abstract
This study reveals that FOXM1-ZIC2-UBE2C-mTOR signaling axis promotes the progression of ccRCC, which can be used as a prognostic indicator and potential therapeutic target.
Topics & Concepts
Cancer researchClear cell renal cell carcinomaGene knockdownBiologyPI3K/AKT/mTOR pathwayCarcinogenesisFOXM1MetastasisProtein kinase BTranscription factorTumor progressionSignal transductionCellCell cycleCancerCell biologyMedicineCell cultureRenal cell carcinomaPathologyGeneGeneticsRenal cell carcinoma treatmentRenal and related cancersFerroptosis and cancer prognosis