Developing a transwell millifluidic device for studying blood–brain barrier endothelium
Ian C. Harding, Nicholas R. O’Hare, Mark Vigliotti, Alex Caraballo, Claire I. Lee, Karina Millican, Ira M. Herman, Eno E. Ebong
Abstract
. Collectively, these results support the necessity of physiologically relevant, multicellular BBB models when investigating BBB EC function. Consideration of the roles of shear stress and supportive cells within the BBB is critical for elucidating the physiology of the neurovascular unit.
Topics & Concepts
PericyteBlood–brain barrierPermeability (electromagnetism)Cell biologyBiophysicsCell cultureBarrier functionAstrocyteEndothelial stem cellChemistryVascular permeabilityCellTight junctionBiologyIn vitroBiochemistryNeuroscienceMembraneGeneticsCentral nervous systemEndocrinologyBarrier Structure and Function StudiesNeurological Disease Mechanisms and TreatmentsIntracerebral and Subarachnoid Hemorrhage Research