Dual role of nitroarenes as electrophiles and arylamine surrogates in Buchwald–Hartwig-type coupling for C–N bond construction
Zhiguo Lei, Jiaxin Yao, Yuxuan Xiao, Wenbo Liu, Lin Yu, Wengui Duan, Chao‐Jun Li
Abstract
A reductive and denitrative amination of nitroarenes has been developed, allowing the highly selective synthesis of various di- and triarylamines. The protocol employed synthetically upstream nitroarenes as both the electrophiles and amine sources.
Topics & Concepts
AminationChemistryCombinatorial chemistryArylElectrophileUllmann reactionAryl halideHalideOrganic chemistryCatalysisAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques