Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone
Chaochao Ge, Yuxia Wang, Yongli Feng, Senzhen Wang, Kemeng Zhang, Xiaojuan Xu, Zhiyang Zhang, Yuan Zhao, Yanming Wang, Lei Gao, Fujun Dai, Songqiang Xie, Chaojie Wang
Topics & Concepts
AutophagyOxidative stressCancer researchOxidative phosphorylationProgrammed cell deathIDH2MitoxantroneReactive oxygen speciesDownregulation and upregulationIsocitrate dehydrogenaseChemistryKEAP1Cell growthMitochondrionApoptosisColorectal cancerBiologyBiochemistryCancerMedicineIDH1Internal medicineEnzymeTranscription factorChemotherapyGeneMutationAutophagy in Disease and TherapyCancer, Hypoxia, and MetabolismMicroRNA in disease regulation