Emergence of a Fatal ST11-KL64 Tigecycline-Resistant Hypervirulent Klebsiella pneumoniae Clone Cocarrying <i>bla</i> <sub>NDM</sub> and <i>bla</i> <sub>KPC</sub> in Plasmids
Jinzhu Huang, Yi Miao, Yaling Yuan, Peiwen Xia, Bingxue Yang, Jiajia Liao, Zijun Dang, Shengli Luo, Yun Xia
Abstract
Infections with CRKP coproducing KPC and NDM currently have limited clinical antibacterial options, and tigecycline is used as the last line of defense for therapy. However, this study found that CR-hvKP infection with tigecycline resistance, which may lead to many bacteria being resistant to most commonly used antibiotics, brought significant challenges to clinical treatment. The clonal propagation of ST11-KL64 CRKP should receive sufficient attention.
Topics & Concepts
TigecyclineKlebsiella pneumoniaeBiologyMicrobiologyPlasmidEffluxCarbapenemAntibiotic resistanceMultilocus sequence typingMeropenemAntibioticsVirologyGeneGeneticsGenotypeEscherichia coliAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyBacterial Identification and Susceptibility Testing