LDHA facilitates immune escape in bladder cancer through H4K5 lactylation-dependent upregulation of PD-L1
Sensheng Tang, Yang Liu, Bo Jin, Tianyang Zhang, Xingbo Wang, Jie Zhao, Zhibin Xu, Wenchao Zhao, Hao Bian, Hao Bian, Yuan Xia, Hui Wang, Maomao Guo, Maomao Guo
Topics & Concepts
Lactate dehydrogenase ADownregulation and upregulationHistone acetyltransferaseBiologyGlycolysisGene knockdownCancer researchPyruvate dehydrogenase complexImmune systemCell biologyHistoneBladder cancerLactate dehydrogenasemicroRNAHistone deacetylaseTranscriptomeAcetyltransferaseP300-CBP Transcription FactorsWarburg effectCancerCoactivatorImmunotherapyRegulation of gene expressionPD-L1EpigeneticsHistone AcetyltransferasesCancer cellAnaerobic glycolysisRNA modifications and cancerCancer, Hypoxia, and MetabolismFerroptosis and cancer prognosis