An efficient synthesis and evaluation of some novel quinazolinone-pyrazole hybrids as potential antiproliferative agents
Abdelaal A. Abdalha, Mohamed H. Hekal
Abstract
A series of new quinazolinones and related compounds has been conveniently synthesized via reaction of (E)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(6-iodo-4-oxo-4H-benzo[d] [1,3] oxazin-2-yl)acrylonitrile (2) with different nitrogen nucleophiles. The structures of the prepared compounds were fully elucidated using IR, 1H-NMR, and 13C-NMR spectra. The newly synthesized compounds were tested in vitro against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, mammary gland breast MCF-7, and colon cancer HCT-116. Some of the tested compounds showed satisfactory activity.
Topics & Concepts
ChemistryQuinazolinonePyrazoleIn vitroAcrylonitrileProton NMRCombinatorial chemistryCarbon-13 NMRNucleophileStereochemistryOrganic chemistryBiochemistryCatalysisCopolymerPolymerQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms