Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption
Leila B. Giron, Emmanouil Papasavvas, Xiangfan Yin, Aaron R. Goldman, Hsin‐Yao Tang, Clovis S. Palmer, Alan Landay, Jonathan Z. Li, John R. Koethe, Karam Mounzer, Jay R. Kostman, Qin Liu, Luis J. Montaner, Mohamed Abdel‐Mohsen
Abstract
The likelihood of HIV rebound after stopping antiretroviral therapy (ART) is a combination of the size of HIV reservoirs that persist despite ART and the host immunological and inflammatory factors that control these reservoirs. Therefore, there is a need to comprehensively understand these host factors to develop a strategy to cure HIV infection and prevent viral rebound post-ART.
Topics & Concepts
LysophosphatidylcholineProinflammatory cytokineViral loadPhospholipidVirus latencyLipid metabolismContext (archaeology)LipidomicsLipidomeGlutaminolysisImmunologyInflammationMetabolismHuman immunodeficiency virus (HIV)PhosphatidylcholineChemistryBiologyViral replicationBiochemistryVirusPaleontologyMembraneGlycolysisHIV-related health complications and treatmentsHIV Research and TreatmentLiver Disease Diagnosis and Treatment