Constructing chiral aza-quaternary carbon centers by enantioselective carbonylative Heck reaction of <i>o</i>-iodoanilines with allenes
Zhengshuai Xu, Chaoren Shen, Hongru Zhang, Peng Wang, Kaiwu Dong
Abstract
The construction of chiral aza-quaternary C-centers <italic>via</italic> C–N bond formation is achieved by a Pd-catalysed asymmetric carbonylative Heck reaction of <italic>o</italic>-iodoanilines with allenes, providing chiral dihydroquinolinone derivatives with moderate to high yield and enantiomeric ratio.
Topics & Concepts
ChemistryEnantioselective synthesisHeck reactionYield (engineering)Quaternary carbonEnantiomerOrganic chemistryMedicinal chemistryCatalysisPalladiumMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Synthesis and Catalysis