Injectable and pH-Sensitive Hyaluronic Acid-Based Hydrogels with On-Demand Release of Antimicrobial Peptides for Infected Wound Healing
Huinan Suo, Mubashir Hussain, Hua Wang, Nuoya Zhou, Juan Tao, Hao Jiang, Jintao Zhu
Abstract
composite hydrogel exhibited on-demand full thickness wound healing in an infected mice model. Therefore, this work provides an efficient strategy to fabricate antibiotic-free hydrogel-based biomaterials for the management of chronic bacteria-infected wounds.
Topics & Concepts
Hyaluronic acidSelf-healing hydrogelsAntimicrobialChemistryAntimicrobial peptidesBacteriaAntibioticsWound healingAntibacterial activityBiochemistryMicrobiologyPolymer chemistrySurgeryOrganic chemistryMedicineBiologyGeneticsAnatomyWound Healing and TreatmentsAntimicrobial Peptides and ActivitiesAntimicrobial agents and applications