Alcohol Dehydrogenases with <i>anti</i>‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
Musa Musa
Abstract
Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.
Topics & Concepts
Enantiopure drugOptically activeAlcoholEnantiomerChemistryOrganic chemistryBiocatalysisEnzymeCatalysisCombinatorial chemistryEnantioselective synthesisIonic liquidEnzyme Catalysis and ImmobilizationMicrobial Metabolic Engineering and BioproductionPharmacogenetics and Drug Metabolism