SHP2 inhibition mitigates adaptive resistance to MEK inhibitors in KRAS-mutant gastric cancer through the suppression of KSR1 activity
Wenfang Zheng, Zhiyi Yang, Ping Song, Yingchao Sun, Pan Liu, Lei Yue, Kaiqi Lv, Xinjie Wang, Yuqin Shen, Jianmin Si, Xue Zhang, Yuehai Ke, Hongqiang Cheng, Weiling Hu
Topics & Concepts
SelumetinibKRASMEK inhibitorCancer researchMAPK/ERK pathwayGene knockdownKinaseCancerMutantChemistryBiologyMedicineBiochemistryInternal medicineColorectal cancerApoptosisGeneProtein Tyrosine PhosphatasesPI3K/AKT/mTOR signaling in cancerGalectins and Cancer Biology