Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC
Pengwen Chen, Wenqian Yang, Taehun Hong, Takuya Miyazaki, Anjaneyulu Dirisala, Kazunori Kataoka, Horacio Cabral
Topics & Concepts
NanocarriersEndosomeCytosolCancer cellIntracellularCell biologyIn vitroLysosomeInternalizationIn vivoDrug deliveryChemistryCellCancer researchCancerBiophysicsBiologyBiochemistryMaterials scienceNanotechnologyEnzymeBiotechnologyGeneticsRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryCellular transport and secretion