Discovery of megapolipeptins by genome mining of a <i>Burkholderiales</i> bacteria collection
Bruno S. Paulo, Michael J. J. Recchia, Sang Hyeon Lee, Claire H. Fergusson, Sean B. Romanowski, Antonio Bencomo Hernández, Nyssa K. Krull, Dennis Y. Liu, Hannah Cavanagh, Allyson Bos, Christopher A. Gray, Brian T. Murphy, Roger G. Linington, Alessandra S. Eustáquio
Abstract
Megapolipeptins show low structural similarity to known natural products, highlighting the advantage of our Burkholderiales genomics-driven and synthetic biology-enabled pipeline to discover novel natural products.
Topics & Concepts
GenomeComputational biologyBiologyGeneticsGeneCarbohydrate Chemistry and SynthesisPlant Pathogenic Bacteria StudiesBiochemical and Structural Characterization