Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors
Bin Zhang, Zhikun Liu, Shengjin Xia, Qingqing Liu, Shao-Hua Gou
Topics & Concepts
ChemistryQuinazolineEGFR inhibitorsOsimertinibGefitinibCell cultureProtein kinase BEpidermoid carcinomaDocking (animal)Epidermal growth factor receptorPharmacologyBiochemistryErlotinibPhosphorylationStereochemistryCancerReceptorBiologyGeneticsMedicineNursingQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsPI3K/AKT/mTOR signaling in cancer