PROTAC chemical probes for histone deacetylase enzymes
Urvashi Patel, Joshua P. Smalley, James T. Hodgkinson
Abstract
their unique degradation mode of action. In this review, we highlight some of the key findings to date in the discovery of PROTACs targeting HDACs by HDAC class and HDAC isoenzyme, current gaps in PROTACs to target HDACs and future outlooks.
Topics & Concepts
Histone deacetylaseEnzymeHDAC11HistoneChemistryHDAC10Histone deacetylase 2Histone deacetylase 5BiochemistryAcetylationCell biologyBiologyDNAGeneProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways