Recent Updates on Radiation Therapy for Pediatric Optic Pathway Glioma
Nalee Kim, Do Hoon Lim
Abstract
Optic pathway glioma (OPG) is a rare tumor located in optic nerve, optic tract, or optic chiasm. Treatment options for OPG include surgery, radiation therapy (RT), and chemotherapy. Although RT may provide favorable long-term outcomes in manner of either adjuvant or salvage aim, chemotherapy-first approach is increasingly performed due to possible late effects of RT. Proton beam RT may allow normal tissue sparing of radiation exposure compared to conventional X-ray treatment. Therefore, proton beam RT is expected to reduce complications from RT. This review discusses the recent updates on oncologic outcomes of OPG, late toxicities following RT, and compares the outcomes between X-ray treatment and proton beam RT.
Topics & Concepts
MedicineOptic nerveRadiation therapyOptic chiasmGliomaChemotherapyProton therapyAdjuvantOncologyRadiologyInternal medicineSurgeryCancer researchOphthalmologyNeurofibromatosis and Schwannoma CasesGlioma Diagnosis and TreatmentMeningioma and schwannoma management