A green approach for the catalyst‐free synthesis of imidazole‐bearing pyrazole moiety using <scp>PEG</scp>‐400 as an efficient recyclable medium as potential anti‐tubercular and anti‐microbial agents
Nayankumar M. Panchani, Khushal M. Kapadiya, H. S. Joshi
Abstract
Abstract Polyethylene glycol‐400 (PEG‐400) is a recyclable and rapid reaction medium for synthesizing a new series of 4‐(3‐[substitutedphenyl]‐4,5‐dihydro‐1‐phenyl‐1 H ‐pyrazol‐5‐yl)‐1 H ‐imidazoles in two‐step procedures by condensation of 1 H ‐imidazole‐4‐carbaldehyde and various acetophenones to form chalcones followed by base‐catalyzed cyclization employing phenyl hydrazine in a catalyst‐free approach. The way of projected approach provides easy work‐up, less reaction time, avoids metal‐based and toxic catalysts, high yield, and reduces the use of carcinogenic organic solvents. The synthesized scaffolds have been screened for their anti‐microbial and anti‐tubercular activity against a set of pathogens.