Viruses in glioblastoma: an update on evidence and clinical trials
Bavani Gunasegaran, Caroline L. Ashley, Felix Marsh‐Wakefield, Gilles J. Guillemin, Benjamin Heng
Abstract
BACKGROUND: Glioblastoma (GB) is a lethal and aggressive brain tumour. While molecular characteristics of GB is studied extensively, the aetiology of GB remains uncertain. The interest in exploring viruses as a potential contributor to the development of GB stems from the notion that viruses are known to play a key role in pathogenesis of other human cancers such as cervical cancer. Nevertheless, the role of viruses in GB remains controversial. METHODS: This review delves into the current body of knowledge surrounding the presence of viruses in GB as well as provide updates on clinical trials examining the potential inclusion of antiviral therapies as part of the standard of care protocol. CONCLUSIONS: The review summarises current evidences and important gaps in our knowledge related to the presence of viruses in GB.