A Cell Culture Model of BK Polyomavirus Persistence, Genome Recombination, and Reactivation
Linbo Zhao, Michael J. Imperiale
Abstract
model to study acute replication exists, no practical model with which to study BKPyV persistence is currently available. We established a BKPyV persistence model in cell culture. Our model reveals that the virus can persist for various periods of time before random recombination of the viral genome leads to enhanced replication.
Topics & Concepts
Subclinical infectionPersistence (discontinuity)VirologyGenomeDiseaseBiologyBK virusImmunologyMedicineGeneticsGeneKidney transplantationKidneyGeotechnical engineeringPathologyEngineeringPolyomavirus and related diseasesFull-Duplex Wireless CommunicationsEnergy Harvesting in Wireless Networks