Paired Electrolysis-Enabled Arylation of Quinoxalin-2(1<i>H</i>)-ones
Jia-Cheng Hou, Jun Jiang, Yan-Cui Wen, Yan-Yan Zeng, Yuhan Lu, Jiasheng Wang, Li‐Juan Ou, Wei‐Min He
Abstract
The first paired electrolysis-enabled arylation of quinoxalin-2(1 H )-ones was achieved using cyanoarenes as the arylation reagents. A variety of 3-arylquinoxalin-2(1 H )-ones with various important functional groups were obtained in moderate to good yields under metal- and chemical oxidant-free conditions. With a pair of reductive and oxidative processes occurring among the substrates and reaction intermediates, the power consumption can be dramatically reduced.
Topics & Concepts
ElectrolysisReagentChemistryCombinatorial chemistryOxidative phosphorylationMetalPower consumptionBulk electrolysisOrganic chemistryPower (physics)BiochemistryElectrodePhysical chemistryPhysicsQuantum mechanicsElectrolyteSynthesis and Biological EvaluationRadical Photochemical ReactionsCO2 Reduction Techniques and Catalysts