Multicomponent Cyclization with an Inorganic Sulfur Dioxide Surrogate: Straightforward Construction of Difluorinated Benzosultams
Yuheng Wu, Cheng-Jing Li, Zhonglin Wei, Wei‐Wei Liao
Abstract
A straightforward three-component transformation for the preparation of functionalized benzosultams under TM-free and mild reaction conditions was described, in which easy-to-handle Na2S2O5, available bromodifluoroalkyl reagent, and N-(2-haloaryl) cyanamide were employed. Na2S2O5 was essential to the generation of difluoroalkyl radical, SO2 fixation, and cyclization, which enabled efficient construction of target products in a sustainable manner. A broad substrate scope and modular feature made this protocol attractive for exploring the chemical space of the construction of cyclic sulfonamides.
Topics & Concepts
ReagentChemistryCyanamideCombinatorial chemistryModular designScope (computer science)Substrate (aquarium)Organic chemistryComputer scienceGeologyOceanographyOperating systemProgramming languageSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsSynthesis and Catalytic Reactions