Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
Yijia Li, Johannes F. Fahrmann, Maryam Aftabizadeh, Qianqian Zhao, S. C. Tripathi, Chunyan Zhang, Yuan Yuan, David K. Ann, Samir Hanash, Hua Yu
Abstract
(Cell Reports 39, 110870; May 31, 2022) In the original version of this paper published on May 31, 2022, the enlarged inset in the image of Ki67 staining in Figure 6D lower panel (without knockdown; shACSL4, Dox-) was erroneously misplaced with the enlarged inset from the upper panel image (without knockdown; shSTAT3, Dox-). The data presented in the figure were correct; the only error was the enlarged inset in the image in Figure 6D lower panel. The figure has been corrected online. The authors sincerely regret any confusion that may have been caused.Figure 6D. Silencing ACSL4 or STAT3 reduces mitochondrial membrane lipids and chemoresistant TNBC tumor growth (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipidsLi et al.Cell ReportsMay 31, 2022In BriefLi et al. demonstrate that FAO mediates chemoresistance in part by acetylating STAT3 through increased acetyl-CoA. Acetylated STAT3 upregulates long-chain acyl-CoA synthetase 4 (ACSL4). Upregulated ACSL4 enhances phospholipid synthesis, which is accompanied by elevated mitochondrial membrane phospholipid levels and strengthened mitochondrial membrane potential. This leads to compromised mitochondrial apoptotic signaling. Full-Text PDF Open Access