Expanding the role of bitter taste receptor in extra oral tissues: TAS2R38 is expressed in human adipocytes
Raffaella Cancello, Giancarlo Micheletto, Dorela Meta, Rosalia Lavagno, Emanuele Bevilacqua, Valerio Panizzo, Cecilia Invitti
Abstract
differentiated adipocytes, bitter agonists induced a significant delipidation. Incubation with 6-n-propylthiouracil induced an inhibition of lipid accumulation rate together with an increase in TAS2R38 and a decrease in genes involved in adipocyte differentiation. In conclusion, TAS2R38 is more expressed in adipocytes of obese than lean subjects and is involved in differentiation and delipidation processes.
Topics & Concepts
EndocrinologyInternal medicinePropylthiouracilAdipose tissueAdipocyteReceptorBiologyMedicineThyroidBiochemical Analysis and Sensing TechniquesAdvanced Chemical Sensor TechnologiesOlfactory and Sensory Function Studies