Histone methyltransferase KMT2A: Developmental regulation to oncogenic transformation
Jayme Ogino, Yali Dou
Abstract
Our current understanding of epigenetic regulation is deeply rooted in the founding contributions of Dr C. David Allis. In 2002, Allis and colleagues first characterized the lysine methyltransferase activity of the mammalian KMT2A (MLL1), a paradigm-shifting discovery that brings epigenetic dysregulation into focus for many human diseases that carry KMT2A mutations. This review will discuss the current understanding of the multifaceted roles of KMT2A in development and disease, which has paved the way for innovative and upcoming approaches to cancer therapy.
Topics & Concepts
MethyltransferaseHistone methyltransferaseHistoneTransformation (genetics)EZH2EpigeneticsBiologyCancer researchCell biologyGeneticsMethylationGeneEpigenetics and DNA MethylationCancer-related gene regulationGenomics and Chromatin Dynamics