Metabolic interactions of host-gut microbiota: New possibilities for the precise diagnosis and therapeutic discovery of gastrointestinal cancer in the future—A review
Jianing Yu, Lu Li, Xufeng Tao, Yanwei Chen, Deshi Dong
Abstract
Gastrointestinal (GI) cancer continues to pose a significant global health challenge. Recent advances in our understanding of the complex relationship between the host and gut microbiota have shed light on the critical role of metabolic interactions in the pathogenesis and progression of GI cancer. In this study, we examined how microbiota interact with the host to influence signalling pathways that impact the formation of GI tumours. Additionally, we investigated the potential therapeutic approach of manipulating GI microbiota for use in clinical settings. Revealing the complex molecular exchanges between the host and gut microbiota facilitates a deeper understanding of the underlying mechanisms that drive cancer development. Metabolic interactions hold promise for the identification of microbial signatures or metabolic pathways associated with specific stages of cancer. Hence, this study provides potential strategies for the diagnosis, treatment and management of GI cancers to improve patient outcomes. • The article emphasizesemphasises the link between dysbiosis of the gastrointestinal microbiota and the development of GI tumours. • Rectifying microbiota disorders improves its distribution may delay or inhibit the growth of GI tumors • We discuss the modulation of host-gut microbiota interactions offers avenues for the discovery of innovative therapies. • The review underscores need for optimal solutions in the treatment of gastrointestinal tumours to enhance patient outcomes.