Synthesis of N-Fused Triazole–Piperazine–Quinazolinones via One-Pot Tandem Click Reaction and Cross-Dehydrogenative Coupling
Ravuri Srinath, Arindam Manna, Subhankar Shee, Vijay Babu Pathi, Saswati Ghosh, Krishnendu Khamaru, Nakul C. Maiti, Biswadip Banerji
Abstract
Herein, a one-pot protocol to synthesize tetracyclic triazole-piperazine-quinazolinone-fused N-heterocyclic scaffolds is reported. In this strategy, a tandem approach of two highly efficient synthetic reactions, click and cross-dehydrogentive coupling reactions, with high atom economy were employed to obtain the target N-fused scaffolds. Being highly functional group tolerable, this method has broad substrate scope. Interestingly, some of these derivatives showed strong white solid-state fluorescence.
Topics & Concepts
ChemistryPiperazineQuinazolinoneTandemCombinatorial chemistryTriazoleClick chemistryCoupling reactionSubstrate (aquarium)Organic chemistryCatalysisOceanographyComposite materialGeologyMaterials scienceQuinazolinone synthesis and applicationsClick Chemistry and ApplicationsHIV/AIDS drug development and treatment