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TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

Alessandro Zambusi, Klara Tereza Novoselc, Saskia Hutten, Sofia Kalpazidou, Christina Koupourtidou, Rico Schieweck, Sven Aschenbroich, Lara A. Gruijs da Silva, Ayse Seda Yazgili, Frauke van Bebber, Bettina Schmid, Gabriel Möller, Clara Tritscher, Christian Stigloher, Claire Delbridge, Swetlana Sirko, Zeynep I. Gunes, Sabine Liebscher, Jürgen Schlegel, Hananeh Aliee, Fabian J. Theis, Silke Meiners, Michael Kiebler, Dorothee Dormann, Jovica Ninkovic

2022Nature Neuroscience58 citationsDOI

Topics & Concepts

MicrogliaZebrafishTraumatic brain injuryCell biologyRegeneration (biology)InflammationLipid dropletNeuroscienceChemistryHomeostasisBiologyMedicineImmunologyBiochemistryGenePsychiatryNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanismsImmune cells in cancer
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury | Litcius