The positive allosteric modulator of the mGlu2 receptor JNJ-46356479 partially improves neuropathological deficits and schizophrenia-like behaviors in a postnatal ketamine mice model
Albert Martínez-Pinteño, Susana García-Cerro, Sergi Mas, Teresa Torres, Daniel Boloc, Natàlia Rodríguez, Amàlia Lafuente, Patricia Gassó, Joan Albert Arnáiz, Eduard Parellada
Topics & Concepts
GlutamatergicDentate gyrusMetabotropic glutamate receptorNeuroscienceAllosteric modulatorNMDA receptorSchizophrenia (object-oriented programming)PsychologyMetabotropic glutamate receptor 2Glutamate receptorHippocampusGABAergicHippocampal formationParvalbuminSpontaneous alternationInternal medicineReceptorMedicineAllosteric regulationPsychiatryInhibitory postsynaptic potentialNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology