Antifungal Peptide SP1 Damages Polysaccharide Capsule of Cryptococcus neoformans and Enhances Phagocytosis of Macrophages
Yan Liu, Yang Zhang, Xi Zhao, Weilai Lu, Yuxin Zhong, Yu Fu
Abstract
C. neoformans is an opportunistic pathogen that causes invasive infections with a high mortality rate. Currently, the clinical drugs available for the treatment of cryptococcosis are limited to amphotericin B, azoles, and flucytosine.
Topics & Concepts
Cryptococcus neoformansMicrobiologyCryptococcosisAntifungal drugAmphotericin BFlucytosineBiologyVirulence factorCryptococcusVirulenceImmune systemCandida albicansImmunologyAntifungalBiochemistryGeneFungal Infections and StudiesAntifungal resistance and susceptibilityNail Diseases and Treatments