VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR
Cheng Liu, Li Liu, Kun Wang, Xiaofeng Li, Liyuan Ge, Runzhuo Ma, Yidong Fan, Luchao Li, Zhengfang Liu, Min Qiu, Yichang Hao, Zhenfeng Shi, Chuanyou Xia, Klas Strååt, Yi Huang, Lulin Ma, Dawei Xu
Topics & Concepts
BiologyCancer researchEpidermal growth factor receptorCarcinogenesisTranscription factorDownregulation and upregulationHypoxia-inducible factorsCell growthTumor progressionClear cell renal cell carcinomaRenal cell carcinomaCancerGeneInternal medicineGeneticsMedicineEpigenetics and DNA MethylationCancer, Hypoxia, and MetabolismRenal cell carcinoma treatment