Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation
Sigrid Gouma, Colleen Furey, Jefferson Santos, Kaela Parkhouse, Madison E. Weirick, Hiromi Muramatsu, Norbert Pardi, Steven H.Y. Fan, Drew Weissman, Scott E. Hensley
Abstract
This study shows that the nucleoside-modified mRNA-LNP vaccine platform is a promising alternative for egg-based influenza vaccines. We show that mRNA-LNP vaccines expressing H3 antigens elicit high levels of antibodies in mice and protect against H3N2 influenza virus infection.
Topics & Concepts
BiologyVirologyStrain (injury)Adaptation (eye)Influenza vaccineVaccinationNeuroscienceAnatomyAnimal Virus Infections StudiesViral gastroenteritis research and epidemiologySARS-CoV-2 and COVID-19 Research