Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis
Precious Ngwalero, James C.M. Brust, Stijn W. van Beek, Sean Wasserman, Gary Maartens, Graeme Meintjes, Anton Joubert, Jennifer Norman, Sandra Castel, Neel R. Gandhi, Paolo Denti, Helen McIlleron, Elin M. Svensson, Lubbe Wiesner
Abstract
Bedaquiline is recommended for the treatment of all patients with rifampin-resistant tuberculosis (RR-TB). Bedaquiline accumulates within cells, but its intracellular pharmacokinetics have not been characterized, which may have implications for dose optimization.
Topics & Concepts
PharmacokineticsBedaquilineIntracellularPharmacologyMetabolitePeripheral blood mononuclear cellMedicineTuberculosisInternal medicineChemistryMycobacterium tuberculosisPathologyBiochemistryIn vitroDrug Transport and Resistance MechanismsTuberculosis Research and EpidemiologyHIV/AIDS drug development and treatment