NIR-excited upconversion nanoparticles used for targeted inhibition of Aβ42 monomers and disassembly of Aβ42 fibrils
Yijia Guan, Weijie Cao, Tao Li, Jieyi Qin, Qilong He, Xiaofeng Jia, Yuqing Li, Yuhua Zhang, Jianguo Liao
Abstract
-ThS and light can be oxidized rather than other normal proteins. To further enhance Aβ-target photooxygenation, we introduced the Aβ-target peptide (KLVFF) on the surface. Compared to traditional chemotherapies and radiotherapies, this novel PDT strategy shows remarkably reduced side effects and improved targeting.
Topics & Concepts
Photon upconversionMaterials scienceFibrilNanoparticleExcited stateMonomerNanotechnologyOptoelectronicsChemical engineeringPolymerBiophysicsComposite materialEngineeringAtomic physicsPhysicsLuminescenceBiologyAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in MaterialsNeuroscience and Neuropharmacology Research