Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea
Siyu Du, Xin Chen, Rumeng Ren, Li Li, Baohui Zhang, Qi Wang, Yan Meng, Zhenpeng Qiu, Guihong Wang, Guohua Zheng, Junjie Hu
Abstract
Total flavonoids in vine tea ameliorated AKT-induced nonalcoholic fatty liver disease in mice by targeting the PPAR signaling pathway, thereby regulating de novo fatty acid synthesis and glycerophospholipid metabolism.
Topics & Concepts
LipidomicsNonalcoholic fatty liver diseaseFatty liverSteatosisProtein kinase BTranscriptomePharmacologyBiologyInternal medicineBiochemistryEndocrinologyMedicineApoptosisDiseaseGene expressionGeneLiver Disease Diagnosis and TreatmentHops Chemistry and ApplicationsLipid metabolism and biosynthesis