Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center
Andrew M. Borman, J M Hughes, Debra Oliver, Mark Fraser, Julie Sunderland, Alan Noel, Elizabeth M. Johnson
Abstract
We determined isavuconazole serum concentrations for 150 UK patients receiving standard isavuconazole dosing regimens, including serial therapeutic drug monitoring for several patients on prolonged therapy. Mean trough isavuconazole concentrations in these patients were virtually identical to those reported previously from clinical trials, although greater variability was seen in patients below 18 years of age. Serial monitoring in patients receiving prolonged therapy suggested gradual, near-linear accumulation of the drug over many weeks.
Topics & Concepts
Therapeutic drug monitoringMedicineDrugCenter (category theory)Intensive care medicinePharmacologyChemistryCrystallographyAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentTuberculosis Research and Epidemiology