Melatonin reverses nasopharyngeal carcinoma cisplatin chemoresistance by inhibiting the Wnt/β-catenin signaling pathway
Jiän Zhang, Tao Xie, Xi Zhong, Huali Jiang, Rong Li, Baiyao Wang, Xiaoting Huang, Bohong Cen, Yawei Yuan
Abstract
, combined treatment with DDP and melatonin reduced tumor burden to a greater extent than single drug-treatments in an orthotopic xenograft mouse model. Our findings provide novel evidence that melatonin inhibits the Wnt/β-catenin pathway in NPC, and suggest that melatonin could be applied in combination with DDP to treat NPC.
Topics & Concepts
Wnt signaling pathwayNasopharyngeal carcinomaMelatoninCisplatinCancer researchIn vivoCateninMetastasisIn vitroSignal transductionBiologyMedicineRadiation therapyInternal medicineChemotherapyCancerCell biologyGeneticsWnt/β-catenin signaling in development and cancerEpigenetics and DNA MethylationCancer Cells and Metastasis